239 - Ketorolac-Propofol vs Fentanyl-Propofol IV Sedation in Uncooperative Children

Purpose: To compare the sedative effect of intravenous (IV) ketorolac-propofol combination with fentanyl-propofol in uncooperative children.

Methods: This prospective randomized double-blind clinical trial was conducted on 30 healthy, 2-6 year-old children, (14F, 16M),  mean age 3.53±1.14. After signed informed consent,  patients were randomly allocated into two groups: Group A received fentanyl (1 µg/kg) and propofol (2mg/kg) at first appointment and ketorolac (1mg/kg) and propofol (2mg/kg) at the second visit. Group B received these medications in reverse order.  An introductory oral midazolam (0.5mg/kg) was administered to all participants 30 mins before IV administration. A maintenance dose of propofol at 150 µg/kg/h was administered along with atropine (0.02mg/kg) during treatment to control salivary secretions. Vital signs including heart rate and pulse oximetry were recorded every 15 mins. Behavior was assessed using the Houpt scale. Data were analyzed using Kolmogorove-Smirnov and Mann-Whitney U tests.

Results: There was no significant differences between the two groups for vital sign values and sedation level (P < .05). No carry over effect was seen in the outcomes assessed (P >.05). All subjects received complete treatment with sedation rated as “achieved”, with no significant difference between groups.  

Conclusion: No statistically significant difference was found in the level of sedation, analgesia, and hemodynamic changes between ketorolac and fentanyl groups.

Identify Supporting Agency and Grant Number: Beheshti University Research Section