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Growth & Development

501 - Disturbances in Dental Maturation and Morphologies Caused by Anti-Cancer Therapy

Saturday, May 25, 2024
1:00 PM – 1:10 PM EST
Location: Exhibit Hall (back left corner of the hall, space 137)

    Presenting Author(s)

  • Taylor Schnebelt, DDS (she/her/hers)

    Pediatric Dental Resident
    Case Western Reserve University — UH Rainbow Babies and Children’s Hospital, Cleveland, OH
    Case Western Reserve University School of Dental Medicine
    Lawrenceburg, Indiana, United States

    • Co-Author(s)

  • GF

    Gerald Ferretti, DDS

    Case Western Reserve University School of Dental Medicine

  • MF

    Margaret Ferretti, DMD

    Case Western Reserve University School of Dental Medicine

    • Program Director(s)

  • MF

    Margaret Elaine Ferretti, DMD

    Program Director
    Case Western Reserve University
    Rainbow Babies and Children's Hospitals, Case Western Reserve University
    cleveland, Ohio, United States

Abstract:

Acute Lymphoblastic Leukemia (ALL) is a hematologic malignancy that is rapid in growth. ALL commonly affects children - accounting for about 25% of childhood cancers. ALL can present systemically as fever, fatigue, bone pain, and swollen lymph nodes. It can manifest orally as gingival bleeding, hyperplasia, and opportunistic infections. Treatment commonly includes chemotherapy, radiation therapy, and bone marrow transplants. Anti-cancer drugs are successful by inhibiting growth of cancer cells with cytostatic and cytotoxic effects. Unfortunately, these cells can disturb normal growth of non-cancerous cells as well – including disturbances of dental development. Common dental abnormalities that result include microdontia, hypodontia, root malformations, enamel defects, and hyperdontia. This presentation discusses an 11-year-old female patient with a history of ALL and chemotherapy/radiation therapy at age 6. This patient presented with over-retained primary teeth due to generalized microdontia in her permanent dentition. This presentation explores the diagnosis of dental anomalies after anti-cancer treatment.

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