140 - Polymorphisms Associated to Periodontitis in Patients with Down Syndrome

Purpose: Determine the presence of polymorphisms CCL5, CCR5 and TNF-a genes, in patients with or without Down Syndrome (DS) affected or not by periodontal disease (PD).


Methods: A case-control investigation was conducted at the Diagnostic Department of the Faculty of Dentistry at the Autonomous University of Yucatan, approved ethically under the reference FODO-2019-0001. The study involved the recruitment of 25 patients with DS exhibiting various stages of PD, while 7 individuals without DS were chosen as controls. Each participant underwent a thorough periodontal examination to confirm the diagnosis. Saliva samples were collected for qPCR analysis to identify the presence of specific polymorphisms. For the polymorphisms, the Hardy-Weinberg frequency and odds-ratio was determined.

Results: The presence of the GA and AA genotypes in the CCR5 G59029A polymorphism, along with the existence of the A allele, it’s a risk for developing PD.

Conclusion: The polymorphism of the CCR5 receptor G59029A might be considered as a contributing factor in patients with Down Syndrome, into increasing the risk of developing periodontitis stage III-IV.


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