123 - Remineralization of Erosive Tooth Wear by Enameguard Mouthwash

Purpose: Erosive tooth wear (ETW) inflicts significant functional and aesthetic damage to teeth, which negatively impacts the patient’s quality of life. The incidence of ETW in children is increasing, therefore the objective of this in vitro study was to evaluate the potential of Enameguard (hydrolyzed wheat protein) mouthwash to remineralize ETW.

Methods: ETW was created on enamel blocks by 10-minute demineralization in 1% citric acid (pH 3.5). Baseline surface microhardness (SMH) of the eroded enamel lesions was measured using a microhardness tester. The blocks (n=80) were randomly assigned to 4 treatment groups (n=20): (A) 2% Enameguard pH 5.5, (B) 2% Enameguard pH 7.0, (C) Pronamel pH 6.2, and (D) Placebo pH 5.5. Groups were subjected to daily pH-cycling consisting of one 2-minute erosive challenge with citric acid, 3 1-minute mouthwash treatment periods, and then storage in artificial saliva for the rest of the time for 14 days. Post-remineralization SMH was measured, and the treatment effects were compared statistically among the groups using ANOVA and Tukey’s multiple comparison test (α=.05).

Results: There were no significant differences among the 3 active mouthwashes. However, each of the 3 active mouthwashes were statistically significantly (P < .02) more efficacious than the placebo mouthwash. Comparison (paired t-test) of the mean values of the post-erosion and post-remineralization SMH within each product indicated a significant (P < .0001) remineralization within each product except the placebo group.

Conclusion: The present study demonstrated that Enameguard mouthwash containing hydrolyzed wheat protein is as effective in remineralizing erosive tooth wear as fluoride mouthwash.

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